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目的:考察25℃与37℃下,盐酸氨溴索注射液与注射用加替沙星在0.9%氯化钠注射液中的配伍稳定性。方法:采用RP-HPLC-二极管阵列检测器测定盐酸氨溴索与加替沙星在0.9%氯化钠注射液中配伍后8 h内各时间段的含量,同时测定pH,观察配伍液的外观变化。结果:在25℃与37℃下、8 h内,配伍液外观、pH及含量均无明显变化。结论:盐酸氨溴索注射液与注射用加替沙星在0.9%氯化钠注射液中8 h,pH、外观、含量基本无变化,微粒检测等尚有待进一步试验。
Objective: To investigate the compatibility of ambroxol hydrochloride injection and gatifloxacin injection in 0.9% sodium chloride injection at 25 ℃ and 37 ℃. Methods: RP-HPLC-diode array detector was used to determine the content of ambroxol hydrochloride and gatifloxacin in 0.9% sodium chloride injection within 8 h. The pH was measured at the same time and the appearance of compatibility solution Variety. Results: There was no significant change in the appearance, pH and content of the compatibility liquid at 25 ℃ and 37 ℃ within 8 h. Conclusion: Ambroxol hydrochloride injection and gatifloxacin injection in 0.9% sodium chloride injection 8 h, pH, appearance, content of the basic unchanged, particle testing remains to be further tested.