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氟哌啶醇(Haloperidol)是临床广泛使用的抗精神病药物,主要用于精神分裂症、躁狂症等疾病的治疗。由于患者长期连续服药,其对人体体细胞毒理遗传效应问题值得探讨。鉴于这方面的研究尚不多见,我们采用了几项细胞遗传学指标就氟哌啶醇对正常人外周血培养细胞染色体的作用进行了系统观察,现将其对核仁形成区影响的观察结果报告如下。一、方法:受试者为无遗传病、肿瘤、射线及致畸药接触史的正常人2例,年龄为23及36岁。在第一组实
Haloperidol is widely used in the clinical antipsychotics, mainly for the treatment of schizophrenia, mania and other diseases. Due to the long-term continuous administration of the drug, the issue of genetic effects on human cytotoxicity is worth discussing. In view of this research is rare, we use several cytogenetic indicators of haloperidol on normal human peripheral blood cell chromosomes were observed, and now its impact on the nucleolus formation observed The results are reported below. First, the method: Subjects without genetic disease, cancer, radiation and teratogenic exposure history of normal 2 cases, aged 23 and 36 years old. In the first group of real