论文部分内容阅读
背景 血管与心脏功能密切相关 ,但以往对血管功能研究较少 ,动脉结构与功能常相互影响 ,功能变化可能早于临床征状 ,较易复查与比较 ,动脉弹性为血管功能最重要指标。目的 本文观察了人群血压 ,脉压与大 ,小动脉弹性指数 (C1,C2 )的关系及影响因素。方法 采用HDIDO 2 0 2 0测定正常人群与血压升高者C1,C2 ,同时采集病史 ,查体及作有关血生化指标。结果 男女人群C1,C2均随SBP ,DBP及脉压升高 (含正常范围 )而明显降低。各层次男性测值均大于女性 ,但老年人及血压大于 160 /90者性别差异减少。单因相关分析 ,C1,C2与年龄、SBP、DBP、脉压呈负相关 ,年龄、SBP、DBP与C2联系强度大于C1。C1随高血压分级增加而降低 ,C2不明显 ,不同类型高血压中ISH之C1,C2下降最明显 ,药物治疗后C1,C2有改善趋势。结论 血压 (即使正常范围 )对C1,C2有巨大影响 ,尤其C2 ;SBP及脉压影响大于DBP ,尤其C1,不同高血压分级与分型对C1,C2影响有差异 ,二、三级高血压对C1及ISH较对C2影响更大。药物有改善C1,C2趋势 ,因检测例数较少尚难结论
Background Blood vessels and cardiac function are closely related, but in the past few studies on vascular function, arterial structure and function often affect each other, functional changes may be earlier than clinical symptoms, easier to review and comparison, arterial elasticity is the most important indicator of vascular function. Objective This study investigated the relationship between blood pressure, pulse pressure and the elasticity index of large and small arteries (C1, C2) and its influencing factors. Methods The HDIDO2020 was used to measure the normal population and the elevated blood pressure of C1 and C2. At the same time, medical history, physical examination and related blood biochemical indexes were collected. Results Both male and female population C1 and C2 were significantly decreased as SBP, DBP and pulse pressure increased (including normal range). Men at all levels were measured more than women, but the elderly and blood pressure greater than 160/90 decreased gender differences. One-way correlation analysis showed that C1, C2 were negatively correlated with age, SBP, DBP and pulse pressure, and age, SBP, DBP and C2 were stronger than C1. C1 decreased with the increase of hypertension grade, C2 was not obvious, the most obvious decrease of C1, C2 of ISH in different types of hypertension, C1, C2 after drug treatment had a tendency of improvement. Conclusions Blood pressure (even in the normal range) has a great influence on C1 and C2, especially C2. The effect of SBP and pulse pressure is greater than that of DBP, especially C1. The effect of different hypertension grading and classification on C1 and C2 is different. Grade two and three hypertension C1 and ISH more influence on C2. Drugs have improved C1, C2 trend, due to fewer test cases is difficult to conclude