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目的：研究促凋亡基因Ｂａｘ在膀胱移行细胞癌（ＴＣＣ）中的表达，探讨Ｂａｘ在ＴＣＣ发生、发展中的作用和预后复发中的意义。方法：采用兔抗人Ｂａｘ多克隆抗体及Ｓ－Ｐ免疫组化法检测。结果：５６例ＴＣＣ中有３４例Ｂａｘ蛋白表达阳性，阳性率６０．７％。２０例正常膀胱粘膜中有６例表达阳性，阳性率３０％。两组差异显著（Ｐ＜０．０５）。Ｂａｘ蛋白表达部位在细胞胞浆中。Ｂａｘ蛋白表达与病理分级、临床分期及肿瘤复发无显著相关性。结论：促凋亡基因Ｂａｘ在大部分ＴＣＣ中具有不同程度的表达与其发生有关，与ＴＣＣ分级、分期及复发无关。
Objective: To investigate the expression of Bax in bladder transitional cell carcinoma (TCC) and to explore the significance of Bax in the occurrence, development and prognosis of TCC. Methods: Rabbit anti-human Bax polyclonal antibody and S-P immunohistochemical method were used. Results: 34 cases of 56 cases of TCC were positive for Bax protein, the positive rate was 60.7%. In 20 cases of normal bladder mucosa, 6 cases were positive, the positive rate was 30%. The difference between the two groups was significant (P <0.05). Bax protein expression in the cytoplasm. Bax protein expression and pathological grade, clinical stage and tumor recurrence no significant correlation. Conclusion: The expression of Bax, a pro-apoptotic gene, in most TCCs is related to its occurrence, but not to the classification, staging and recurrence of TCC.