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目的： 观察卡孕栓直肠给药用于晚期妊娠引产的有效性及安全性。方法： 将晚期妊娠因医学指征需引产者８５ 例，除２５ 例胎膜早破者全部直肠给药外，余６０ 例随机分为直肠给药组及阴道给药组， 比较两种给药方式引产的有效率，分娩方式， 用药距宫缩出现时间，临产时间及总产程、副反应等。结果： 两种给药方式引产的有效率比较，差异无显著性（ Ｐ＞ ０ ．０５） ； 分娩方式，总产程时间比较差异亦无显著性（ Ｐ ＞ ０ ．０５） ；但用药距出现宫缩时间和临产时间，直肠给药组明显快于阴道给药组。结论：卡孕栓直肠给药与阴道给药用于晚期妊娠引产同样安全、有效， 且更为简便。卡孕栓直肠给药引产者重点监护时间应早于阴道给药者，一般在用药后３０ ｍｉｎ 至４ｈ 。
Objective: To observe the effectiveness and safety of carbachol for rectal administration in late pregnancy. Methods: 85 cases of late pregnancy due to medical indications required induction of labor, except for 25 cases of premature rupture of membranes were all rectal administration, the other 60 were randomly divided into rectal administration group and vaginal administration group, the two administration The efficiency of induction of labor, mode of delivery, medication from the time of contractions, labor time and the total production process, side effects. Results: There was no significant difference in the rate of induction of labor between the two modes of administration (P> 0.05); there was no significant difference in the mode of delivery and the duration of labor (P> 0.05) Reduction time and labor time, rectal administration group was significantly faster than the vaginal administration group. CONCLUSION: Cathepsis suppositories for rectal administration and vaginal delivery are equally safe, effective and simpler for induction of labor during late pregnancy. Cathepsis suppository rectal administration of induction of key monitoring time should be earlier than vaginal administration, usually 30 min to 4 h after treatment.