小字征(micrographia)作为帕金森病(Parkinson’s disease,PD)的一个重要体征早已被认可,国内、外教课书中已屡有提及(图1B)。唯大字征自帕金森本人最早报道6例起,迄今近200年的国内、外文献中均未提及。笔者在一次门诊中,偶然发现1例PD患者,书写时字不是越写越小,而是越写越大(图1A,C)。为此对这一现象予以了特别关注。在近5年的门诊工作中,对所有就诊 Micrographia has long been recognized as an important sign of Parkinson’s disease (PD), and has been frequently mentioned in domestic and foreign teaching books (Figure 1B). The only large character from the first report of 6 cases since Parkinson’s own, so far nearly 200 years of domestic and foreign literature are not mentioned. In an outpatient clinic, I accidentally found that 1 patient with PD was not writing smaller and smaller, but writing more and more (Figure 1A, C). To this end has given special attention to this phenomenon. In nearly five years of out-patient work, for all visits