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目的观察喜炎平联合阿昔洛韦治疗小儿手足口病的效果。方法将手足口病80例按双盲法随机分为治疗组和对照组,每组40例。对照组仅使用阿昔洛韦治疗,治疗组在对照组基础上加用喜炎平治疗。对2组患儿临床疗效及细胞因子水平进行检测对比。结果治疗组总有效率为97.50%高于对照组的87.50%(P<0.05);治疗后2组白细胞介素-1β(IL-1β)、白细胞介素-10(IL-10)和肿瘤坏死因子-α(TNF-α)的水平均降低,且治疗组低于对照组,差异均有统计学意义(P<0.05)。结论临床使用喜炎平联合阿昔洛韦治疗小儿手足口病,患者症状改善好、细胞因子水平恢复好,值得临床推广应用。
Objective To observe the effect of Xiyanping combined with acyclovir in the treatment of hand-foot-mouth disease in children. Methods 80 cases of HFMD were randomly divided into treatment group and control group by double-blind method, 40 cases in each group. The control group only treated with acyclovir, the treatment group was treated with xiyanping on the basis of the control group. On the two groups of children with clinical efficacy and cytokine levels were compared. Results The total effective rate was 97.50% in the treatment group and 87.50% in the control group (P <0.05). After treatment, the levels of IL-1β, IL-10 and tumor necrosis (TNF-α) levels were lower, and the treatment group than in the control group, the difference was statistically significant (P <0.05). Conclusion Xiyanping combined with acyclovir in the treatment of children with hand-foot-mouth disease, the patient’s symptoms improved, cytokines recovered well, worthy of clinical application.