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患者男,46岁,住院号56706,因患甲状腺功能亢进、糖尿病,于1980年11月5日入院。入院时T36℃、P100次、BP110/70,化验:Hb11g、RBC437万、WBC4600、N67%、L33%、空腹血糖87mg%、尿糖(-)、经服他巴唑30mg/日治疗至第七周,患者突发咽痛、寒战、高热39～40.7℃,持续2周。血红蛋白下降至8.1g、WBC550(N.%)、RBC274万、他巴唑网织红细胞0%,血小板1万,空腹血糖400mg%、尿糖+++、骨髓象极度抑制。引起急性粒细胞缺乏症,相继出现急性再生障碍性贫血、中毒性肝损害、败血症、肺部感染,右足蜂窝织炎伴右足背外侧湿性坏死,右足第4趾干性坏死,重症糖尿病,低钠高氯性酸中毒、低钾血症,药物性血小板减少性紫瘢,高渗性脱水致精神障碍、低蛋白血症(水肿)、输血反应致血管内溶血(血红蛋白尿)、甲亢危象、继发性尿崩症
Male, 46 years old, hospital number 56706, was hospitalized on November 5, 1980 due to hyperthyroidism and diabetes. Admission T36 ℃, P100 times, BP110 / 70, laboratory tests: Hb11g, RBC4.37 million, WBC4600, N67%, L33%, fasting blood glucose 87mg%, urine sugar (-), by metoprazole 30mg / Week, patients with sudden sore throat, chills, fever 39 ~ 40.7 ℃, for 2 weeks. Hemoglobin decreased to 8.1g, WBC550 (N.%), RBC274 million, 0% of methimazole reticulocytes, platelets 10000, fasting blood glucose 400mg%, urine sugar + + +, bone marrow like extreme inhibition. Acute agranulocytosis, followed by acute aplastic anemia, toxic liver damage, sepsis, lung infection, right foot cellulitis with right lateral dorsal wet necrosis, right foot 4th toe dry necrosis, severe diabetes, low sodium Hyperchlorinated acidosis, hypokalemia, drug-induced thrombocytopenic purpura, hypertonic dehydration-induced mental disorders, hypoalbuminemia (edema), intravascular hemolysis (hemoglobinuria) due to transfusion reactions, hyperthyroidism crisis, Secondary diabetes insipidus