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目的研究重症监护病房(Intensive Care Unit,ICU)患者感染的不动杆菌分布及耐药性特征,指导ICU合理用药治疗感染性疾病。方法对我院2006~2008年ICU患者送检标本分离的213株不动杆菌的分布及耐药性进行回顾性统计分析。结果ICU患者感染不动杆菌以50岁以上老年男性为主;以下呼吸道标本为主,3年共有166例,占77.9%(166/213);3年来共检出五种菌,以鲍曼氏不动杆菌和醋酸钙不动杆菌为主,其次为洛菲氏不动杆菌;不动杆菌多重耐药严重,且耐药率高。结论ICU患者感染不动杆菌呈逐年增多趋势,耐药现象严重,对全部氨基青霉素、一代、二代头孢菌素和一代喹诺酮类抗生素天然耐药,可选用泰能、头孢四代(头孢吡肟)、头孢三代+酶抑制剂(舒普深)等治疗。
Objective To study the distribution and drug resistance of Acinetobacter spp. Infection in Intensive Care Unit (ICU) patients and to guide the rational use of ICU in the treatment of infectious diseases. Methods The distribution and drug resistance of 213 Acinetobacter isolated from the ICU patients in our hospital from 2006 to 2008 were retrospectively analyzed. Results Infectious Acinetobacter in the ICU patients were mainly in the elderly over 50 years old. The following respiratory specimens were the main samples in three years with a total of 166 cases (77.9%) (166/213) Acinetobacter and Acinetobacter mainly, followed by Acinetobacter baumannii; Acinetobacter multi-drug resistance is serious, and the high rate of resistance. Conclusion Acinetobacter in ICU patients showed an increasing trend year by year with serious drug resistance. Natural resistance to all aminopenicillin, first and second generation cephalosporins and first generation quinolone antibiotics may be selected from the group consisting of tetranidine, cefepime ), Three generations of cephalosporin enzyme inhibitors (Shu Pu deep) and other treatment.