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目的观察血管紧张素转换酶抑制剂(ACEI)在肾脏病中的作用。方法分析我院从2000年1月至2008年1月期间对常规用利尿剂加钙拮抗剂与其联合ACEI,在肾脏病中的治疗效果。结果 ACEI可以很好地控制血压,降低尿蛋白及血浆肌酐浓度,从而延缓肾损害的进程。结论 ACEI通过阻止血管紧张素Ⅱ的生成,降低血浆血管紧张素Ⅱ浓度和减少醛固酮分泌,从而使周围小动脉扩张,降低血压。能减少蛋白尿,明显延缓肾功能恶化,保护肾脏。
Objective To investigate the role of angiotensin converting enzyme inhibitor (ACEI) in renal disease. Methods From January 2000 to January 2008 in our hospital for routine use of diuretics and calcium antagonists combined with ACEI in the treatment of renal disease. Results ACEI can well control blood pressure, reduce urinary protein and plasma creatinine concentration, thereby retarding the progression of renal damage. Conclusion ACEI can prevent the formation of angiotensin Ⅱ, decrease the concentration of plasma angiotensin Ⅱ and decrease the secretion of aldosterone, so as to expand the surrounding arterioles and lower the blood pressure. Can reduce proteinuria, significantly delayed renal function deterioration, protect the kidneys.