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目的:探索乙肝疫苗常规全程免疫后抗-HBs无应答儿童的再次免疫方案。方法:将自2003年1月起乙肝疫苗常规全程免疫后抗-HBs无应答的95名儿童(7个月~12岁)随机分为A、B、C 3组。分别采用不同再次免疫方法:A组30人,给予乙肝疫苗、左旋咪唑涂布剂、免疫球蛋白;B组30人给予乙肝疫苗、左旋咪唑涂布剂;C组35人,单纯注射乙肝疫苗。结果:抗-HBs总阳转率为86.73%,A、B、C各组抗-HBs阳转率分别为100%、90%、80%。结论:乙肝疫苗常规免疫后,给予抗-HBs无应答儿童再次免疫的效果是肯定的。
Objective: To explore the re-immunization program of children without response to anti-HBs after routine whole-dose immunization of hepatitis B vaccine. METHODS: Ninety-five children (7 months to 12 years old) who did not respond to anti-HBs after routine immunization of hepatitis B vaccine since January 2003 were randomized into groups A, B and C. A group of 30 people were given hepatitis B vaccine, levamisole coating agent and immunoglobulin respectively; group B, hepatitis B vaccine and levamisole were given to 30 people; Group C, 35 people were injected with hepatitis B vaccine alone. Results: The total positive conversion rate of anti-HBs was 86.73%. The positive conversion rates of anti-HBs in groups A, B and C were 100%, 90% and 80% respectively. CONCLUSIONS: The effect of re-immunization of non-responders with anti-HBs was confirmed after routine immunization of hepatitis B vaccine.