目的探讨炎性因子、血小板参数水平对感染性休克患者预后判断的意义。方法 80例感染性休克患者根据预后分为存活组56例,死亡组24例。分别于不同时间检测2组的降钙素原(PCT)、C-反应蛋白(CRP)、血小板宽度(PDW)、血小板压积(PCT)水平并评估2组的APACHEII评分。结果入院时,死亡组的炎性因子PCT、CRP,血小板参数PDW及APACHEII评分均显著高于存活组差异有统计学意义(P<0.05)。存活组炎性因子PCT、CRP,血小板参数PDW及APACHEII评分均随着治疗时间的延长而显著降低(P<0.05),血小板参数PCT水平随治疗时间延长而增加(P<0.05)。而死亡组的上述指标变化趋势与存活组相反。炎性因子PCT、CRP,血小板参数PDW水平与APACHEII评分呈正相关(P<0.05),而血小板参数PCT水平与APACHEII评分呈负相关(P<0.05)。结论动态监测炎性因子参数和血小板参数水平有助于感染性休克患者病情的危重程度和预后的判断。 Objective To investigate the significance of inflammatory factors and platelet parameters in the prognosis of septic shock patients. Methods Eighty septic shock patients were divided into survival group (56 cases) and death group (24 cases) according to the prognosis. The levels of procalcitonin (PCT), C-reactive protein (CRP), platelet width (PDW) and platelet pressure (PCT) were measured at different time points and APACHEII scores of two groups were evaluated. Results At admission, the inflammatory factors PCT, CRP, platelet parameters PDW and APACHEII score in death group were significantly higher than those in survival group (P <0.05). PCT, CRP, platelet parameters PDW and APACHEII score of survival group were significantly decreased with the prolongation of treatment time (P <0.05). The platelet parameter PCT level increased with the prolongation of treatment time (P <0.05). In the death group, the trend of the above indicators was opposite to that in the survival group. PCT, CRP and platelet parameter PDW were positively correlated with APACHEII score (P <0.05), while platelet parameter PCT level was negatively correlated with APACHEII score (P <0.05). Conclusion The dynamic monitoring of inflammatory cytokines and platelet parameters may be helpful for judging the severity and prognosis of patients with septic shock.