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基因组不稳定是癌症的特征之一,而细胞DNA损伤应答及其修复机制异常是导致基因组不稳定的重要原因。所有类型的DNA损伤中,DNA双链断裂是最严重的一种,DNA双链断裂修复机制与多种肿瘤的发生发展和治疗密切关联,现就子宫内膜癌中的DNA双链断裂修复研究进展做一综述,以期为未来靶向DNA修复通路的研究和治疗提供理论参考。
Genomic instability is one of the characteristics of cancer, and DNA damage and cell repair mechanisms of abnormal cell genome lead to instability is an important reason. In all types of DNA damage, DNA double-strand breaks are the most serious one. The mechanism of DNA double-strand break repair is closely related to the occurrence, development and treatment of many kinds of tumors. Now we study the repair of DNA double-strand breaks in endometrial carcinoma This review will provide a theoretical reference for the future research and treatment of targeting DNA repair pathways.