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目的观察影响手术切除ⅢA-N2非小细胞肺癌的预后的因素,为提高其手术治疗效果提供依据。方法搜集我院52例采用手术治疗的ⅢA-N2期非小细胞肺癌患者的资料,比较不同性别、年龄组、吸烟与否、N2分期、T分期、手术方式、术前血清CEA、LDH水平和术后是否放、化疗等患者的5年生存率差异。结果 52例患者的中位生存期为29个月,5年累计生存率为23.08%。男性和女性患者的5年生存率无明显差异(22.86%Vs 23.53%),而高龄组、吸烟组的5年生存率(9.09%,0%)明显低于低龄组(33.33%)和不吸烟组(31.58%)。单因素及多因素生存分析结果提示年龄、吸烟、N2分期、T分期、术前血清CEA、LDH水平和术后是否放、化疗等均与患者术后生存期有关。结论年龄、吸烟、N2分期、T分期、手术方式、术前血清CEA、LDH水平和术后是否放、化疗等是影响患者预后的重要因素。
Objective To observe the factors affecting the prognosis of surgical resection of ⅢA-N2 non-small cell lung cancer and provide the basis for improving the effect of surgical treatment. Methods The data of 52 patients with stage ⅢA-N2 non-small cell lung cancer who underwent surgical treatment in our hospital were collected. The differences of gender, age group, smoking or not, N2 stage, T stage, operation mode, preoperative serum CEA and LDH levels and Postoperative radiotherapy, chemotherapy and other patients 5-year survival rate difference. Results The median survival time of 52 patients was 29 months. The 5-year cumulative survival rate was 23.08%. There was no significant difference in 5-year survival rate between male and female patients (22.86% Vs 23.53%), while the 5-year survival rate (9.09%, 0%) in the elderly group and the smoking group was significantly lower than that in the younger group (33.33% Group (31.58%). Univariate and multivariate survival analysis showed that age, smoking, N2 staging, T staging, preoperative serum CEA, LDH levels and postoperative radiotherapy or chemotherapy were all related to postoperative survival. Conclusion Age, smoking, N2 stage, T stage, operation mode, preoperative serum CEA, LDH level and postoperative chemotherapy and radiotherapy are the important factors affecting the prognosis of patients.