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目的分析佛山市三水区中老年人群高尿酸的发病率,及其与体重指数、血酯、胰岛素抵抗指数、血糖的相关性。方法通过尿酸、血糖、空腹胰岛素及血脂等生化检查调查佛山市三水区35岁以上中老年人群3 326名,以55周岁中位点分为中年组和老年组,每组再根据血尿酸(SUA)水平分为高尿酸组和尿酸正常组,分别对照各组性别、体重指数(BMI)、血糖(FPG)、总胆固醇(TCHO)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、胰岛素抵抗指数(HOMA-IR)水平。结果中年组和老年组高尿酸发病率分别为21.17%、32.11%,老年组显著高于中年组,差异有统计学意义(P<0.05)。中年组中高尿酸组BMI、FPG、TG、HOMA-IR显著高于尿酸正常组(P<0.01),且与性别相关;老年组中高尿酸组BMI、FPG、TG、HOMA-IR显著高于尿酸正常组(P<0.01),且与性别无相关。老年组中高尿酸组HOMA-IR显著高于中年组中高尿酸组,差异有统计学意义(P<0.01)。结论高龄、男性、高体重指数、高甘油三酯的人群中高尿酸发病率增高,高尿酸血症与胰岛素抵抗呈正相关。
Objective To analyze the incidence of hyperuricemia in middle-aged and elderly people in Sanshui District of Foshan City and its correlation with body mass index, blood ester, insulin resistance index and blood sugar. Methods A total of 3 326 elderly people aged over 35 in Sanshui District of Foshan City were investigated by biochemical tests such as uric acid, blood glucose, fasting insulin and serum lipids. The middle-aged and elderly patients were divided into middle-aged group and old-aged group at 55 years old. (SUA) were divided into high uric acid group and normal uric acid group. The levels of serum lipids (BMI), blood glucose (FPG), total cholesterol (TCHO), low density lipoprotein cholesterol (LDL- Ester (TG), insulin resistance index (HOMA-IR) levels. Results The incidences of high uric acid in middle-aged and elderly groups were 21.17% and 32.11% respectively, significantly higher in the elderly group than in the middle-aged group (P <0.05). The levels of BMI, FPG, TG and HOMA-IR in hyperuricemia group were significantly higher than those in normal uric acid group (P <0.01) Normal group (P <0.01), and no correlation with gender. The HOMA-IR in the hyperuric group was significantly higher in the elderly group than in the middle-aged group, the difference was statistically significant (P <0.01). Conclusion The incidence of hyperuricemia in elderly, men, high body mass index, and high triglyceride patients is higher than that in normal controls. There is a positive correlation between hyperuricemia and insulin resistance.