胶质母细胞瘤(glioblastoma,GBM)是成年人大脑最好发的恶性肿瘤,大约占所有脑内肿瘤的15%,占原发性恶性脑肿瘤的45%~50%~([1-2])。GBM在任何年龄均可发病,发病高峰55~85岁,小于40岁发病的很少。GBM最好发于大脑半球白质和灰质深部。影像学表现为肿瘤周边不规则环形强化影。病变进展迅速,临床症状主要取决于病变的部位,主要是偏瘫和言语障碍。临床治疗主要是手术 Glioblastoma (glioblastoma, GBM) is the best malignant tumor in adult brain, accounting for about 15% of all brain tumors, accounting for 45% ~ 50% of primary malignant brain tumors 2]). GBM can be onset at any age, the peak incidence of 55 to 85 years old, less than 40 years of age rarely. GBM is best in the cerebral hemispheres white matter and gray matter deep. Imaging showed irregular circumferential enhancement around the tumor. Rapid progress of the disease, clinical symptoms mainly depend on the lesion site, mainly hemiplegia and speech disorders. Clinical treatment is mainly surgery