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一氧化氮（ＮＯ）为由广泛存在于机体组织中的ＮＯ合成酶（ＮＯＳ）催化Ｌ－精氨酸（Ｌ－Ａｒｇ）和分子氧而合成的一种自由基气体，在血管结构中调节全身内环境，可舒张血管，调节血管张力，抑制血小板的粘附聚集，调节白细胞的活化。最新的研究表明，ＮＯ尚可抑制血管损伤诱导的新内膜形成（ＮＩＦ），而血管平滑肌细胞（ＶＳＭＣｓ）的增殖、迁移和表型转换在ＮＩＦ中有重要作用。作者就ＮＯ对ＮＩＦ过程中ＶＳＭＣｓ功能的影响作一综述。
Nitric oxide (NO) is a free radical gas synthesized from L-arginine (L-Arg) and molecular oxygen catalyzed by NO synthase (NOS), which is widely found in body tissues. Internal environment, can relax blood vessels, regulate vascular tone, inhibit platelet adhesion and aggregation, regulating leukocyte activation. Recent studies have shown that NO still inhibits neointimal formation (NIF) induced by vascular injury, whereas proliferation, migration and phenotypic turnover of vascular smooth muscle cells (VSMCs) play an important role in NIF. The authors review the impact of NO on the function of VSMCs during NIF.