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目的 观察COAVP16方案对老年小细胞肺癌化疗的效果及探讨影响疗效的因素。方法 采用COAVP16方案对17例老年小细胞肺癌患者进行化疗。结果 完全缓解(CR)3例,部分缓解(PR)9例,进展(PD)5例。11例有不同程度的骨髓抑制,8例呈肝功轻度损害及消化道反应。经对症治疗,停药后均恢复正常。总有效率(CR+PR)为70.6％。结论 COAVP16方案适合老年小细胞肺癌病人生理特点,治疗效果较好。
Objective To observe the effect of COAVP16 regimen on chemotherapy for senile small cell lung cancer and to explore the factors influencing the curative effect. Methods 17 cases of elderly patients with small cell lung cancer were treated with COAVP16 regimen. Results 3 cases were complete remission (CR), 9 cases were partial remission (PR) and 5 cases were progression (PD). Eleven patients had different degrees of myelosuppression, eight patients had mild liver damage and gastrointestinal reactions. After symptomatic treatment, withdrawal were normal after withdrawal. The total effective rate (CR + PR) was 70.6%. Conclusion The COAVP16 regimen is suitable for patients with small cell lung cancer and has good therapeutic effect.