论文部分内容阅读
目的:观察拉莫三嗪添加治疗难治性癫癎的疗效、用药方法、剂量及副作用。方法:对54例难治性癫癎患者进行添加拉莫三嗪治疗,观察其疗效。结果:拉莫三嗪添加治疗难治性癫癎,总有效率达83％,37例(69％)患者发作停止。对全面性发作有效率达83％,对部分性发作及部分性发作继发全面性强直阵挛性发作有效率达80％。平均有效剂量96．8±27．3mg／d,37例无发作病例平均剂量为77．8±17．5 mg／d。2例加量12．5 mg／d后发作加重,减量后控制良好。除1例发生轻微皮肤瘙痒外,无中枢神经系统及其他副作用,满意度为96％。结论:拉莫三嗪添加治疗难治性癫癎有良好疗效,副作用轻微,一天一次用药效果可靠,一般患者有效剂量在150mg／d内。
Objective: To observe the effect of lamotrigine in the treatment of refractory epilepsy, the method of administration, dosage and side effects. Methods: Fifty-four patients with refractory epilepsy were treated with lamotrigine and the curative effect was observed. Results: Lamotrigine added refractory epilepsy, the total effective rate was 83%, 37 patients (69%) patients with seizures stopped. The effective rate of 83% of comprehensive seizures, partial seizures and partial seizures secondary to comprehensive tonic clonic seizures effective rate of 80%. The average effective dose was 96.8 ± 27.3mg / d, and the average number of 37 patients without episodes was 77.8 ± 17.5 mg / d. Two cases of additional dose of 12.5 mg / d exacerbation after the reduction of good control. In addition to 1 case of mild skin itching, no central nervous system and other side effects, satisfaction was 96%. CONCLUSION: Lamotrigine is effective in treating refractory epilepsy with mild side effects. The effective dose of 150mg / d is generally within one day.