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近年来,金属配合物与DNA键合的研究以及引起的生物效应的研究受到十分重视。顺铂,碳铂与DNA的共价键合,以及由此引起的DNA构象变化的研究已成为弄清它们抗癌作用机理的焦点。80年代中期以来,Barton等人又发现含平面芳香配体的手性八面体构型的配合物对DNA双螺旋体的键合具有立体选择性,并将手性[Ru(Phen)_3]~(3+)发展成为识别B型和Z型DNA的探针。最近他们还发现[Rh(Phen)_2Phi]~(3+)(Phi=9,10-Phenanthre-
In recent years, metal complexes and DNA binding research and the biological effects caused by the research received great attention. Cisplatin, covalent bonding of carboplatin to DNA, and the resulting changes in DNA conformation have become the focus of elucidation of their anti-cancer mechanisms. Since the mid-1980s, Barton et al. Also found that complexes containing chiral octahedral configuration of planar aromatic ligands have stereoselectivity for DNA double-spiro bonding and chiral [Ru (Phen) 3] 3+) to become probes that recognize both type B and type Z DNA. Recently, they also found that [Rh (Phen) _2Phi] ~ (3 +) (Phi = 9,10-Phenanthre-