子宫内膜间质肉瘤往往通过染色体易位导致基因融合,最终调控表观遗传学的改变。迄今为止,仅发现YWHAENUTM2重排与高级别形态学和侵袭性的临床生物学行为有关。作者报道3例形态学上模拟子宫黏液样型平滑肌肉瘤的子宫内膜间质肉瘤,并描述其独特的组织病理学特征,通过采用新一代测序确定其基因遗传学改变。3例子宫内膜 Endometrial stromal sarcoma often leads to genetic fusion through chromosomal translocation, ultimately regulating epigenetic changes. To date, only YWHAENUTM2 rearrangements have been found to be associated with high-level morphological and invasive clinical biological behavior. The authors report three cases of endometrial stromal sarcoma that morphologically mimic leiomyosarcoma of the uterine myxoid and describe their unique histopathological features and determine their genetic genetic changes by using a new generation of sequencing. 3 cases of endometrium