论文部分内容阅读
目的 研究体部伽玛刀治疗早期非小细胞肺癌的临床疗效。方法 对18 例I~II期非小细胞肺癌病例采用体部伽玛刀立体定向放射治疗,负压袋体模固定体位,螺旋CT增强扫描定位和三维适形治疗计划。处方剂量5Gy/次,5次/周,共10次,以50%等剂量曲线作为参考线。结果 原发灶完全缓解(CR) 12 例(66.7%),部分缓解(PR)6例(33.3%),无变化(NR)0例,总有效率(CR+PR)100%。18 例治疗按计划完成,放射性肺炎多数较轻,I级占27.8%(5/18),II级占5.6%(1/18)。1、2年肿瘤局部控制率分别为94.4%、77.8%。结论 体部伽玛刀治疗早期非小细胞肺癌近期疗效好,放射反应轻微,分次立体定向适形放疗是较为理想的放疗模式,可提高肿瘤的局部控制率。
Objective To study the clinical efficacy of body gamma knife in the treatment of early non-small cell lung cancer. Methods 18 cases of stage I-II non-small cell lung cancer cases were treated with Gamma Knife stereotactic radiotherapy, negative pressure bag phantom fixed position, spiral CT enhanced scan positioning and three-dimensional conformal treatment plan. Prescription dose 5Gy / time, 5 times / week, a total of 10 times, 50% isodose curve as a reference line. Results There were 12 cases (66.7%) of complete remission (CR), 6 cases (33.3%) of partial remission (PR), 0 cases of no change (NR) and 100% of total effective rate (CR + PR). Eighteen treatments were completed as planned, and most of the patients with radiation pneumonitis were lighter, with I grade 27.8% (5/18) and II class 5.6% (1/18). The local control rates of tumors in 1 and 2 years were 94.4% and 77.8% respectively. Conclusion Gamma knife treatment of early non-small cell lung cancer with short-term curative effect, mild radiotherapy, and fractionated stereotactic radiotherapy is an ideal radiotherapy model, which can improve the local control rate of tumors.