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目的 :探讨基质金属蛋白酶 -9(MMP -9)的表达与膀胱移行细胞癌浸润、转移和预后的关系。方法 :采用免疫组织化学方法检测 61例膀胱移行细胞癌组织及 2 3例癌旁组织基质金属蛋白酶 -9的表达。结果 :膀胱移行细胞癌MMP -9表达与侵袭程度成正相关 (P <0 .0 1 ) ,预后不良组膀胱移行细胞癌MMP -9表达显著高于预后良好组 (P <0 .0 1 )。结论 :MMP -9的表达与膀胱移行细胞癌的侵袭、转移和预后有关 ,是膀胱移行细胞癌侵袭、转移较好的分子标志 ,可用于膀胱移行细胞癌的预后判断。
Objective: To investigate the relationship between the expression of matrix metalloproteinase-9 (MMP-9) and infiltration, metastasis and prognosis of bladder transitional cell carcinoma. Methods: Immunohistochemical method was used to detect the expression of matrix metalloproteinase-9 in 61 cases of transitional cell carcinoma of the bladder and 23 cases of paracancerous tissues. Results: The expression of MMP-9 in bladder transitional cell carcinoma was positively correlated with the degree of invasion (P <0.01). The expression of MMP-9 in bladder transitional cell carcinoma with poor prognosis was significantly higher than that in well-prognosis group (P <0.01). Conclusion: The expression of MMP-9 is related to the invasion, metastasis and prognosis of transitional cell carcinoma of the bladder. It is a good molecular marker for the invasion and metastasis of transitional cell carcinoma of the bladder and can be used for the prognosis of bladder transitional cell carcinoma.