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目的 探讨丙型病毒性肝炎的发病机制。方法 在重型肝炎患者肝组织中用直接酶标法检测 HCAg。结果 在99例慢性重型肝炎患者的肝组织中检测 HCAg阳性 9例 (9.1% ) ;HCAg阳性的肝细胞呈单个散在分布或 3～ 5个呈簇状分布 ,其表达方式分为三种 :胞浆均质型 (2 / 9)、包涵体型 (4 / 9)、核型 (3/ 9)。本组 HCAg阳性肝细胞少量散在分布与肝细胞本身的病变无明显相关性 ,可见 HCAg阳性肝细胞位于坏死灶的周边 ,在 HCAg阳性肝细胞的周围有淋巴细胞浸润。结论 HCV可能通过细胞免疫反应引起肝细胞损伤
Objective To investigate the pathogenesis of hepatitis C virus. Methods Direct ELISA was used to detect HCAg in the liver tissue of patients with severe hepatitis. Results Ninety-nine cases (9.1%) of HCAg positive were detected in liver tissues of 99 patients with chronic severe hepatitis. HCAg-positive hepatocytes were scattered or clustered in 3 ~ 5 clusters. The expression patterns were divided into three types: Plasma homogenate (2/9), inclusion body type (4/9), karyotype (3/9). Small group of HCAg-positive hepatocytes in this group scattered distribution and liver cell disease itself was not significantly correlated, visible HCAg-positive hepatocytes in the vicinity of the necrosis, HCAG-positive hepatocytes around the lymphocyte infiltration. Conclusion HCV may induce hepatocellular injury through cellular immune response