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AIM:To study the effects of Radix Puerariae flavones (RPF)on liver lipid metabolism in ovariectomized (OVX) rats.METHODS:Forty adult female Wistar rats were randomlydivided into four groups:OVX group;sham-OVX group;OVX+estrogen group and OVX+RPF group.One week afteroperation rats of the first two groups were treated withphysiological saline,rats of OVX+estrogen group withestrogen (1 mg/kg.b.w.) and rats of OVX+RPF group withRPF (100 mg/kg.b.w.),respectively for 5 weeks.Alter therats were killed,their body weight,the weight of theabdominal fat and uterus were measured,and the levels oftotal cholesterol (TC) and triglycedde (TG) in liver homogenatewere determined.RESULTS:Compared with the sham-OVX group,the bodymass of the rats in OVX group was found increased significantly;more abdominal fat in store;TC and TG in liver increased anduterine became further atrophy.As a result,the RPF wasfound to have an inhibitive action on those changes of variousdegrees.CONCLUSION:RPF has estrogen-like effect on lipidmetabolism in liver and adipose tissue.
AIM: To study the effects of Radix Puerariae flavones (RPF) on liver lipid metabolism in ovariectomized (OVX) rats. METHODS: Forty adult female Wistar rats were differentiated into four groups: OVX group; sham- OVX group; OVX + estrogen group and OVX + RPF group. One week afteroperation rats of the first two groups were treated with physiologic saline, rats of OVX + estrogen group withestrogen (1 mg / kg.bw) and rats of OVX + RPF group with RPF (100 mg / kg.bw) , respectively for 5 weeks. Alter therats were killed, their body weight, the weight of the abdominal fat and uterus were measured, and the levels of total cholesterol (TC) and triglycedde (TG) in liver homogenate determined .RESULTS: Compared with the sham- OVX group, the bodymass of the rats in OVX group was found increased significantly; more abdominal fat in store; TC and TG in liver increased anduterine became further atrophy. As a result, the RPF wasfound to have an inhibitive action on those changes of variousdegrees .CONCLUSION: RPF has estrogen-like effect on lipidmetabolism in liver and adipose tissue.