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用皮下注射醋酸可的松６周建立实验大鼠肺孢子虫肺炎动物模型，并用国产蒿甲醚进行试验治疗。治后大鼠肺组织超薄切片透射电镜观察，发现蒿甲醚可导致卡氏肺孢子虫产生以下３种超微结构改变：（１）胞浆内出现大量空泡；（２）线粒体肿胀；（３）核膜破裂。以上改变与戊烷脒对照组相似。
Animal models of Pneumocystis carinii pneumonia were established by subcutaneous injection of cortisone acetate for 6 weeks and were treated with domestic artemether. Observed by ultra-thin section of the lung tissue of the treated rats by transmission electron microscopy, artemether can lead to Pneumocystis carinii the following three kinds of ultrastructural changes: (1) a large number of cytoplasm vacuoles; (2) mitochondria swelling; (3) nuclear membrane rupture. The above changes were similar to pentamidine control group.