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目的探讨肾衰宁颗粒联合沙格列汀片治疗糖尿病肾病的的临床疗效。方法选取2015年9月—2016年8月云南省第二人民医院收治的糖尿病肾病患者70例,按照随机数字表法分为对照组和治疗组,每组各35例。对照组口服沙格列汀片,5 mg/次,1次/d。治疗组在对照组基础上口服肾衰宁颗粒,5 g/次,3次/d。两组均连续治疗8周。观察两组的临床疗效,比较两组血糖、肾功能和炎症因子的情况。结果治疗后,对照组和治疗组的总有效率分别为65.71%、88.57%,两组比较差异有统计学意义(P<0.05)。治疗后,两组空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、血尿素氮(BUN)、尿白蛋白排泄率(UAER)和血清胱抑素C(Cys-C)均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组BUN、UAER和Cys-C的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-18(IL-18)均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论肾衰宁颗粒联合沙格列汀片治疗糖尿病肾病具有较好的临床疗效,能显著改善患者肾功能,降低血糖,减轻炎症反应,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Shenshuaining granule combined with Saxagliptin in the treatment of diabetic nephropathy. Methods Seventy patients with diabetic nephropathy who were admitted to Second People’s Hospital of Yunnan Province from September 2015 to August 2016 were randomly divided into control group and treatment group according to random number table method, with 35 cases in each group. The control group oral saxagliptin tablets, 5 mg / time, 1 / d. Treatment group on the basis of the control group, oral administration of Shenshuaning particles, 5 g / times, 3 times / d. Both groups were treated for 8 weeks. The clinical effects of the two groups were observed, and the blood sugar, renal function and inflammatory factors were compared between the two groups. Results After treatment, the total effective rates of the control group and the treatment group were 65.71% and 88.57%, respectively, with significant difference between the two groups (P <0.05). After treatment, fasting blood glucose (FBG), Hb A1c, BUN, UAER and Cys-C were significantly decreased in both groups. In the same group The difference between before and after treatment was statistically significant (P <0.05). The decrease of BUN, UAER and Cys-C in the treatment group was significantly better than that in the control group. There was significant difference between the two groups (P <0.05). The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-18 (IL-18) were significantly decreased in both groups after treatment (P <0.05). And the decrease of these indexes in the treatment group was obviously better than that in the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion Shenshuaining granule combined with saxagliptin tablets has a good clinical curative effect on diabetic nephropathy, can significantly improve renal function, reduce blood sugar, reduce inflammation, and has certain clinical application value.