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目的 探讨高血压与胰岛素抵抗之间的关系。方法 2型糖尿病高血压组 110例 ,正常血压组112例。测定FPG、FINS、TC、MAU、血压、计算BMI,并评价胰岛素抵抗和 β细胞功能采用稳态模式评估法及改良胰岛素敏感性指数公式计算。结果 高血压组ISI显著低于正常血压组 ,HOMA βcell、HOMA IR显著高于正常血压组 (P <0 0 0 5 ) ,正常体重者也有相同的结果 (P <0 0 5 )。两组ISI与FPG、FINS、BMI均呈显著负相关 (P <0 0 5 ) ,高血压组ISI与TC、TG呈弱负相关 (P <0 5 )。结论 2型糖尿病伴高血压病人无论是否肥胖都存在胰岛素抵抗。肥胖病人胰岛素抵抗更为严重。
Objective To investigate the relationship between hypertension and insulin resistance. Methods 110 cases of type 2 diabetes mellitus and 112 cases of normotensive group. FPG, FINS, TC, MAU, blood pressure were measured, BMI was calculated, and insulin resistance and β-cell function were evaluated using the steady state model and modified insulin sensitivity index formula. Results The ISI of hypertension group was significantly lower than that of normotensive group. HOMA βcell and HOMA IR were significantly higher than those of normotensive group (P <0.05), and those with normal weight also had the same result (P <0.05). There was a significant negative correlation between ISI and FPG, FINS and BMI in both groups (P <0.05). ISI was negatively correlated with TC and TG in hypertensive group (P <0.05). Conclusion Type 2 diabetes mellitus patients with hypertension have insulin resistance whether obese or not. Insulin resistance in obese patients is more serious.