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目的:探讨正常孕11~13+6周母体子宫动脉血流频谱特征,为临床早期筛查和预防子痫前期提供一定的依据。方法:选择行早孕期颈项透明层测量筛查唐氏综合征的正常单胎孕妇347例,采用彩色多普勒超声检测孕妇双侧子宫动脉搏动指数(PI)、阻力指数(RI)和收缩期峰值与舒张末期峰值比值(S/D);比较不同孕周、初产妇与经产妇各参数的差异,记录双侧子宫动脉频谱有无舒张早期切迹。结果:早孕期血流频谱参数平均值分别为:PI为1.92±0.42、RI为0.78±0.07、S/D为5.39±1.85,第95百分位数分别为2.60、0.88、8.83;早孕期不同孕周之间的子宫动脉参数差异无统计学意义(P>0.05);初产妇与经产妇之间差异无统计学意义(P>0.05);双侧子宫动脉切迹发生率为26.80%(93/347);当RI>0.8时,左侧子宫动脉频谱舒张早期切迹发生率为70.89%(112/158),右侧为72.72%(104/143)。结论:正常孕11~13+6周母体子宫动脉血流频谱各项参数值均处于较稳定水平,舒张早期切迹发生率与RI值有关。
Objective: To investigate the spectrum of maternal uterine arterial blood flow during normal pregnancy from 11 to 13 + 6 weeks and provide some evidences for early screening and prevention of preeclampsia. Methods: A total of 347 normal singleton pregnant women were screened for the detection of Down’s syndrome using the transparent layer of neck during the first trimester. The bilateral uterine artery pulsatility index (PI), resistance index (RI) and systolic phase were measured by color Doppler sonography. Peak and end-diastolic peak ratio (S / D); comparison of different gestational weeks, primipara and maternal parameters of the difference between the records of bilateral uterine artery with or without early diastolic notch. Results: The average blood flow parameters of early pregnancy were: PI was 1.92 ± 0.42, RI was 0.78 ± 0.07, S / D was 5.39 ± 1.85, the 95th percentile was 2.60, 0.88, 8.83, respectively; There was no significant difference in uterine artery parameters between gestational weeks (P> 0.05). There was no significant difference between primipara and maternal (P> 0.05). The incidence of bilateral uterine artery incision was 26.80% (93 / 347). When RI> 0.8, the frequency of early diastolic notch in left uterine artery was 70.89% (112/158) and right side was 72.72% (104/143). Conclusion: The values of maternal uterine arterial blood flow spectrum in the period of 11-13 + 6 weeks of pregnancy are all at a stable level, and the incidence of early diastole is related to RI.