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目的观察采用顺铂治疗癌性胸水的疗效。方法尽量排净癌性胸水后,将顺铂100 mg注入胸腔,每周1次,共2次,随后行全身化疗2个周期。结果1995年1月至2006年3月共治疗27例癌性胸水患者,完全缓解(CR)14例,部分缓解(PR)11例,无效(NC)2例,有效率(CR+PR)92.6%,中位生存期11.5个月。结论顺铂对癌性胸水的疗效确切,无严重毒副作用。
Objective To observe the efficacy of cisplatin in the treatment of malignant pleural effusion. Methods After draining cancerous pleural effusion, 100 mg of cisplatin was infused into the thoracic cavity once a week for 2 times, followed by 2 cycles of systemic chemotherapy. Results From January 1995 to March 2006, 27 patients with cancerous pleural effusion were treated. Complete remission (CR) in 14, partial remission (PR) in 11, and ineffective (NC) in 2 patients were achieved. The response rate was (CR + PR) 92.6 %, Median survival 11.5 months. Conclusion Cisplatin is effective in cancerous pleural effusion and has no serious side effects.