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对印尼产糖胶树Alstonia scholaris R.Br.树皮中所含生物碱的研究鲜有报道。作者从该植物树皮中分离出1新的吲哚生物碱(1)、1新的糖生物碱(2)和5个已知生物碱(3～7)。并对这7个化合物进行了抗疟活性研究。该植物干燥、粉碎的树皮用95％乙醇提取,蒸干溶剂,提取物用3％盐酸和乙醚分配,水层用氢氧化钠碱化pH至10,并用氯仿提取得到粗生物碱部位。该部位用NP闪蒸色谱法和RP-HPLC分离或精制,多种溶剂洗脱得化合物1～7。化合物1和2均为浅黄
There are few reports on the alkaloids contained in the bark of Indonesian scholarship scholarship R.Br. The author isolated a new indole alkaloid (1), a new glycoalkaloid (2) and five known alkaloids (3-7) from the bark of the plant. And these 7 compounds were studied for antimalarial activity. The dried, crushed bark of the plant was extracted with 95% ethanol and the solvent was evaporated. The extract was partitioned with 3% hydrochloric acid and ether. The aqueous layer was basified to pH 10 with sodium hydroxide and extracted with chloroform to give crude alkaloid fractions. This fraction was isolated or purified by NP flash chromatography and RP-HPLC, and Compounds 1 to 7 were eluted with various solvents. Compounds 1 and 2 are light yellow