目的研究一种新型鬼臼类抗肿瘤药物。方法根据拼合原理合成一种新的鬼臼类似物,并测定了其体外对肿瘤细胞的活性及在多种介质中的稳定性。结果合成的化合物在体外对P-388,A-549和Bel-7402肿瘤细胞表现出比 VP-16更强的抑制活性。同时固体样品对温度、光等因素的改变较稳定, 而在人工胃液(AGJ)及pH较高的缓冲溶液中和高湿度条件下稳定性较差。结论本试验的结果为该化合物的进一步研究提供了研究基础。 Objective To study a new type of podophyllotoxin antitumor drug. Methods A new podophyllotoxin analogue was synthesized according to the principle of splice. The activity of the podophyllotoxin in vitro and the stability of the podocyte in various media were also determined. Results The synthesized compounds showed more potent inhibitory activity on P-388, A-549 and Bel-7402 tumor cells than VP-16 in vitro. At the same time, the changes of solid, temperature, light and other factors are more stable, while the stability is poor under the conditions of artificial gastric juice (AGJ), high pH buffer solution and high humidity. Conclusion The results of this study provide the basis for further study of this compound.