【摘 要】
：
A new β-resorcylic macrolide,5′-hydroxyzearalenol(1),was isolated from the culture broth of a marine-derived fungus Fusarium sp.05ABR26.Three known compounds,
【机 构】
：
Institute of Molecular and Cellular Biosciences,The University of Tokyo,Tokyo 113-0032,Japan,
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
A new β-resorcylic macrolide,5′-hydroxyzearalenol(1),was isolated from the culture broth of a marine-derived fungus Fusarium sp.05ABR26.Three known compounds,zearalenone(2),8′-hydroxyzearalenone(3)and zearalenol(4)were also isolated.The structure and relative stereoehemistry of 1 were elucidated on the basis of spectroscopic data and single-crystal X-ray diffraction data.Compound 2 displayed potent inhibitory activity against Pyricularia oryzae with a MIC value of 6.25μg/mL, while compound 3 was much less active;however,1 and 4 showed no obvious activity.
A new β-resorcylic macrolide, 5’-hydroxyzearalenol (1), was isolated from the culture broth of a marine-derived fungus Fusarium sp. 05ABR26.Three known compounds, zearalenone (2), 8’-hydroxyzearalenone (3) (4) were also isolated from the structure and relative stereoehemistry of 1 were elucidated on the basis of spectroscopic data and single-crystal X-ray diffraction data. Compound 2 displayed potent inhibitory activity against Pyricularia oryzae with a MIC value of 6.25 μg / mL while compound 3 was much less active; however, 1 and 4 showed no obvious activity.
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