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目的 研究P -糖蛋白 (P -gp)的谷胱甘肽 -S -转移酶 (GAT -π)在肾细胞癌组织中的表达及临床意义。方法 用免疫组化方法检测 40例肾细胞癌术前进行化疗的和 15例正常肾组织中的P -gp和GST -π表达。结果 P -gp和GST -π在 15例正常肾组织中的表达率均为 10 0 % ,在 40例肾细胞癌组织中分别为 6 7 5 %和 5 7 5 % ,P -gp和 (或 )GST -π阳性率为 75 %。P -gp和GST -π的表达与其组织学类型有关 ,与肿瘤的分化程度无关。结论 检测P -gp和GST -π对肾细胞癌病人的治疗方案选择和预后判断具有重要的临床意义
Objective To investigate the expression and clinical significance of glutathione S-transferase (GAT-π) of P-glycoprotein (P-gp) in renal cell carcinoma. Methods The expressions of P-gp and GST-π in 40 cases of renal cell carcinoma before chemotherapy and 15 cases of normal renal tissue were detected by immunohistochemistry. Results The positive rates of P-gp and GST-π were all 10 0% in 15 cases of normal renal tissues and 67.5% and 57 5% in 40 cases of renal cell carcinoma respectively. The expressions of P-gp and ) GST-π positive rate of 75%. The expression of P-gp and GST-π was related to the histological type, but not to the degree of tumor differentiation. Conclusion The detection of P-gp and GST-π has important clinical significance in treatment options and prognosis of patients with renal cell carcinoma