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本研究旨在从两个方面检查高渗氯化钠溶液在休克复苏中的作用。首先,在猪的非致命性失血模型中比较用7.5％氯化钠液或林格氏乳酸盐(RL)液(RL:失血=3:1)复苏后血流动力学和电解质的变化。在此模型中,静脉输注7.5％氯化钠液(2400mOsm)4ml/kg可补充12％的失血量,观察到在放血后1小时和治疗后55分钟,7.5％氯化钠组比无治疗组和RL组的心输出量(COP)均高。在刚用过7.5％氯化钠液后,有些猪的COP比放血前还高。减少7.5％氯化钠液输注量,观察到放血后2小时比1小时时的COP轻度减少。输注1小时RL液,观察到放血后1和2小时时的COP稳定增加。这些表明RL液容量对COP的影响比7.5％
The aim of this study was to examine the role of hypertonic sodium chloride solution in shock resuscitation from two aspects. First, the hemodynamic and electrolyte changes after resuscitation with 7.5% sodium chloride solution or Ringer’s lactate (RL) solution (RL: blood loss = 3: 1) were compared in a non-lethal model of blood loss in pigs. In this model, IV infusion of 7.5% sodium chloride solution (2,400 mOsm) at 4 ml / kg supplemented 12% of the amount of blood loss. It was observed that in the 7.5% sodium chloride group one hour after exsanguination and 55 minutes after treatment Cardiac output (COP) was higher in both groups and RL group. After using 7.5% sodium chloride solution, the COP of some pigs was higher than before bleeding. A 7.5% reduction in sodium chloride infusion was observed and a slight decrease in COP was observed at 2 hours and 1 hour after exsanguination. The RL fluid was infused for 1 hour and a steady increase in COP at 1 and 2 hours after bleeding was observed. These show that the effect of RL fluid volume on COP is less than 7.5%