丝氨酸蛋白酶的激肽释放酶相关肽酶家族中某些成员具有蛋白水解酶活性,有可能影响肿瘤的演进。然而这些活性酶在体内的作用仍不十分清楚。研究者已证实了表达PSA或KLK4而非KLK2的PC-3细胞形态从上皮样变为纺锤形,E-cadherin表达显著降低,vi mentin表达增高,细胞迁移能力增强,即 Some members of the kallikrein-related peptidase family of serine proteases have proteolytic enzyme activity that may affect tumor progression. However, the role of these active enzymes in vivo remains poorly understood. Researchers have demonstrated that the morphology of PC-3 cells expressing PSA or KLK4 but not KLK2 changes from epithelial to spindle-shaped, with a significant decrease in E-cadherin expression, an increase in vimentin expression, and an increased cell migration capacity,