论文部分内容阅读
目的探讨妊娠期高血压疾病患者白介素-1β(IL-1β)、一氧化氮(NO)、肿瘤坏死因子(TNF-α)、瘦素(Leptin)的相关性。方法选取2010年6月～2012年12月在我院住院妊娠期高血压疾病(HDCP)患者70例,根据病情分为妊娠期高血压组(GH)30例,轻度子痫前期组(MP)20例,重度子痫前期组(SP)20例,同期妊娠末期健康孕妇30例为对照组。监测IL-1β、NO、TNF-α、瘦素的测定。结果妊娠期高血压疾病组NO浓度水平显著低于对照组,TNF-α、Leptin血清水平明显高于对照组,妊娠期高血压疾病患者胎盘组织中白介素-1β(IL-1β)mRNA水平显著高于正常孕妇。差异有统计学意义。结论 IL-1β、NO、TNF-α、Leptin的测定对妊娠高血压疾病的筛查诊断治疗有价值,可作为临床应用。
Objective To investigate the correlation between interleukin-1β (NO), tumor necrosis factor (TNF-α) and leptin in patients with gestational hypertension. Methods Seventy patients with hypertensive disorders of pregnancy (HDCP) hospitalized in our hospital from June 2010 to December 2012 were divided into 30 cases of gestational hypertension group (GH), 30 cases of mild preeclampsia group (MP) ), 20 cases of severe preeclampsia group (SP) 20 cases, the same period of pregnancy, 30 healthy pregnant women as control group. The levels of IL-1β, NO, TNF-α and leptin were measured. Results The level of NO in gestational hypertension group was significantly lower than that in the control group. The serum levels of TNF-α and Leptin were significantly higher than those in the control group. The levels of interleukin-1β (IL-1β) mRNA in the placenta of hypertensive disorder complicating pregnancy were significantly higher In normal pregnant women. The difference was statistically significant. Conclusion The determination of IL-1β, NO, TNF-α and Leptin may be valuable in screening and diagnosis of pregnancy-induced hypertension.