三甲基硅化腈是一种常用的有机合成试剂.对近年来三甲基硅化腈在有机合成中的应用进行了简要的总结和概述,重点介绍了三甲基硅化腈作为强的亲核试剂广泛用于环氮和环氧化合物的开环反应、亚胺和醛酮类化合物的加成、胺与醛或酮参与的多组分反应、偶联反应以及对炔和具有较高活性的碳碳双键的氰化加成等反应。 Trimethylsilyl nitrile is a kind of commonly used organic synthesis reagent.It summarizes and summarizes the application of trimethylsilyl cyanide in organic synthesis in recent years, and emphatically introduces trimethylsilyl nitrile as strong nucleophile It is widely used in the ring-opening reaction of ring nitrogen and epoxy compounds, addition of imines and aldehydes and ketones, multi-component reactions involving amines and aldehydes or ketones, coupling reactions, and alkyne and higher carbon Carbon double bond cyanidation and other reactions.