结节性肾上腺皮质增生的病理生理学还不清楚,但可区分为两种不同的疾病。凡肉眼可见结节性增生,有一个以上的结节者(大小不等,直径常达数厘米),同时有肾上腺皮质增生。增生的程度不等,但病程长的病例可有萎缩表现。关键问题是肾上腺的功能是受垂体控制抑或是自主的。这种情况发生在20～40%的柯兴综合征病人,表明有一个从垂体依赖到肾上腺自主的转变过程。未经治疗的柯兴综合征病人,5年死亡率为50%。患巨结节增生的 The pathophysiology of nodular adrenocortical hyperplasia is unclear but can be distinguished into two distinct diseases. Any visible nodular hyperplasia, there are more than one nodule (size range, often several centimeters in diameter), while adrenal hyperplasia. The degree of hyperplasia range, but the duration of the disease may have atrophic cases. The key question is whether the function of the adrenal gland is pituitary-controlled or autonomous. This condition occurs in 20-40% of Cushing’s patients, suggesting a transition from pituitary to adrenal autonomic. The untreated Cushing’s syndrome has a 5-year mortality rate of 50%. Suffering from giant nodular hyperplasia