本文报告了在大剂量化疗和放疗后用异基因周围血干细胞移植重建造血功能治疗儿童恶性血液病的研究结果。 供周围血干细胞(PBPC)者5例,为病人的同胞,年龄7个月～23岁,体重为10～79kg,PBPC采集前均应用粒细胞集落刺激因子(G-CSF)每天10μg/kg,连用4天,第5天由静脉用血细胞分离器采集PBPC,采集CD34~+细胞不低于4×10~6/kg,置于-196℃液氮中保存备用。病人男3例,女2例,年龄1～10岁。急性淋巴细 This article reports the results of a study of treating hematologic malignancies in children with allogeneic peripheral blood stem cell transplantation following high-dose chemotherapy and radiotherapy. Five patients with peripheral blood stem cells (PBPCs) were siblings of patients aged 7 months to 23 years with a body weight of 10 to 79 kg. Before administration of PBPC, 10 μg / kg of G-CSF was applied, For 4 days, on the 5th day, PBPCs were collected by venous blood cell separator, and the CD34 + cells collected were not less than 4 × 10 ~ 6 / kg and stored in liquid nitrogen at -196 ℃ for later use. There were 3 males and 2 females, aged from 1 to 10 years old. Acute lymphoid