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目的:观察肺炎支原体(MP)肺炎患儿血清白胞介素8(IL-8)和白细胞介素10(IL-10)的变化及阿奇霉素治疗对其的影响。方法:以2007年1月~2010年5月连续收治的MP肺炎患儿56例为研究对象(MP组),给予阿奇霉素治疗,疗程7天;同时选择同期的健康儿童50例为正常对照组。用ELISA法检测两组治疗前后血清IL-8和IL-10水平的变化,观察阿奇霉素治疗MP肺炎的临床疗效。结果:阿奇霉素治疗MP肺炎总有效率为96.4%。与正常对照组比较,MP组治疗前血清IL-8水平显著升高,IL-10水平明显下降(均P<0.05);阿奇霉素治疗后,MP组患儿血清IL-8水平下降,IL-10水平升高,接近正常对照组(均P<0.05)。结论:阿奇霉素可降低肺炎支原体肺炎患儿血清IL-8水平,提高IL-10的水平。
Objective: To investigate the changes of serum interleukin-8 (IL-8) and interleukin-10 (IL-10) in children with Mycoplasma pneumoniae pneumonia and the influence of azithromycin treatment. Methods: From January 2007 to May 2010, 56 consecutive children with MP pneumonia were enrolled in this study. The patients were treated with azithromycin for 7 days. Fifty healthy children of the same period were selected as normal control group. Serum levels of IL-8 and IL-10 were measured by ELISA before and after treatment, and the clinical efficacy of azithromycin in the treatment of MP pneumonia was observed. Results: The total effective rate of azithromycin in MP pneumonia was 96.4%. Compared with the normal control group, serum IL-8 level was significantly increased and IL-10 level was significantly decreased in MP group before treatment (all P <0.05). After azithromycin treatment, serum IL-8 level in MP group was decreased, IL- The level was higher than normal control group (all P <0.05). Conclusion: Azithromycin can reduce serum IL-8 in children with Mycoplasma pneumoniae pneumonia and increase the level of IL-10.