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FBW7(F-box and WD repeat domain-containing7,FBW7)为F-box蛋白家族成员,是SCF型泛素连接酶复合物的底物识别蛋白,介导细胞内多种蛋白质经泛素-蛋白酶体途径降解。FBW7通过靶向降解多种癌蛋白如Mcl-1、Notch、HIF-1α、Cyclin E和KFL5等,参与调控细胞增殖、分化、凋亡及肿瘤转移等多种生物学过程。作为一种肿瘤抑制蛋白,FBW7基因突变或缺失存在于多种人类肿瘤中,如白血病、乳腺癌、卵巢癌、胆管癌等,并在这些肿瘤的发生和发展中发挥重要作用。因此,针对FBW7的深入研究有助于理解肿瘤的发生发展机制以及开发肿瘤治疗新方案。本文就FBW7调控的癌蛋白研究进展作一综述。
FBW7, a member of the F-box protein family, is a substrate recognition protein of the SCF-type ubiquitin ligase complex and mediates the upregulation of various proteins in the cell by the ubiquitin-proteasome Way to degradation. FBW7 is involved in many biological processes such as cell proliferation, differentiation, apoptosis and tumor metastasis by targeting a variety of oncoproteins such as Mcl-1, Notch, HIF-1α, Cyclin E and KFL5. As a tumor suppressor protein, FBW7 gene mutations or deletions exist in many human tumors such as leukemia, breast cancer, ovarian cancer and cholangiocarcinoma, and play an important role in the occurrence and development of these tumors. Therefore, in-depth study of FBW7 helps to understand the mechanism of tumor development and development of new programs for the treatment of cancer. This review summarizes the research progress of FBW7 oncoprotein.