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作者应用中国仓鼠卵巢(CHO)细胞重组乙型肝炎疫苗(含乙型肝炎病毒S和前S2蛋白)对1988年8月至1991年9月间出生于法国波利尼西亚群岛的582名婴儿进行接种。免疫方案有3种,方案Ⅰ,0、1、2、12月;方案Ⅱ,0、1、6月;方案Ⅲ,0、1、12月。分别于1989、1990和1991年10～11月采血,用各种试剂盒检测乙型肝炎病毒标志,用ELISA检测抗-前S2滴度,抗-HBs和抗-前S2滴度分别≥10mIU/ml和≥40mU/ml定为血清阳转。
The authors vaccinated 582 infants born in French Polynesia between August 1988 and September 1991 using Chinese Hamster Ovary (CHO) cell recombinant hepatitis B vaccine (including hepatitis B virus and pre-S2 protein). There are three kinds of immunization programs, program Ⅰ, 0, 1, 2, December; program Ⅱ, 0, 1, 6 months; program Ⅲ, 0, January and December. Blood samples were collected from 1989 to 1990 and from October to November 1991 respectively. Hepatitis B virus was detected by various kits. The anti-preS2 titer was detected by ELISA. The anti-HBs and anti-preS2 titers were ≥10 mIU / ml and ≥ 40mU / ml as seroconversion.