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胺碘酮(乙胺碘呋酮)属苯骈呋喃衍生物,其化学结构与甲状腺素相似,是广谱抗快速心律失常药物,具有增加冠状动脉血流,减低心肌氧耗但不显著影响心排血量等作用。1967年用于抗心绞痛,1970年用作抗心律失常药,疗效卓著,目前已在临床上广泛应用。由于本品的药浓度难于测定,有关其药代动力学的报告也较少,国内尚未见有报道。本文报告我院自1979年12月以来治疗124例快速心律失常住院患者的疗效,并对其血药浓度和药效之间关系进行初步探讨。
Amiodarone (amiodarone) is a benzofuran derivative, its chemical structure and thyroid hormone similar to broad-spectrum anti-tachyarrhythmia drugs, with increased coronary blood flow, reduce myocardial oxygen consumption but did not significantly affect the heart Blood volume and other effects. 1967 for anti-angina pectoris, anti-arrhythmic drugs used in 1970, outstanding efficacy, has been widely used in clinical practice. As the drug concentration is difficult to determine the drug, the pharmacokinetics of the report is also less, there have been no reports in China. This article reports 124 cases of hospitalized patients with tachyarrhythmia in our hospital since December 1979 and the preliminary study of the relationship between plasma concentration and pharmacodynamics.