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目的:对比观察阿曲库铵和罗库溴铵的量-效关系和恢复时相特征。方法:选择60例ASAⅠ级,年龄18～50岁,施择期整形外科手术的患者,随机平均分成阿曲库铵组和罗库溴铵组。用60%NO_2-O_2-硫喷妥钠-芬太尼维持麻醉;通过加速度仪监测神经肌肉功能,采用TOF刺激方式,以T_1抑制的百分比为研究指标。采用累计给药方法建立阿曲库铵和罗库溴铵的量-效关系曲线。结果:根据量-效关系曲线,阿曲库铵和罗库溴铵的作用强度比率为1:1．2,两药的ED_(50)、ED_(90)和ED_(95)均有显著性差别。应用等效剂量(1．5×ED_(95))后,两药的高峰时间、临床作用时间和体内作用时间具有显著性差别,但恢复时间无显著性差别。结论:阿曲库铵和罗库溴铵均是弱效能的中效非去极化肌肉松弛药。与阿曲库铵相比,罗库溴铵的作用强度大约弱20%,而且作用时间较短。
OBJECTIVE: To compare the dose-response and recovery phase characteristics of atracurium and rocuronium. Methods: Sixty patients with ASA grade I, aged 18 to 50 years, undergoing elective plastic surgery were randomly divided into atracurium group and rocuronium group. Anesthesia was maintained with 60% NO 2 O 2 -thiopentanil-fentanyl; neuromuscular function was monitored by accelerometer, and TOF stimulation was used as the percentage of T 1 inhibition. The dose-effect relationship curves of atracurium and rocuronium were established by cumulative administration method. Results: According to the dose-effect relationship curve, the ratio of the intensities of atracurium to rocuronium was 1: 1.2. The ED 50, ED 90 and ED 95 of the two drugs were significant difference. After application of equivalent dose (1.5 × ED_ (95)), the peak time, clinical action time and in vivo action time of two drugs had significant difference, but the recovery time had no significant difference. CONCLUSIONS: Both atracurium and rocuronium are weakly effective, non-depolarizing muscle relaxants. Compared with atracurium, rocuronium is about 20% weaker and has a shorter duration of action.