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本实验采用正交设计方案,观察了碱性纤溶酶对家犬冠状动脉血栓的溶栓效果,以尿激酶为对照.结果显示:栓龄、药物剂量及给药速度为影响溶栓效果的主要因素,药物剂量为次要因素,各种给药方案间无显著差异(P>O.05).碱性纤溶酶和尿激酶组再通时间和再闭塞时间及手术中切口渗血量相似(P>0.05).经冠状动脉输注碱性纤溶酶,对铜圈法所致犬冠状动脉血栓可取得与尿激酶相当的溶栓效果.
In this experiment, an orthogonal design scheme was used to observe the thrombolytic effect of alkaline plasmin on coronary thrombosis in dogs. Urokinase was used as a control. The results showed that the age of thrombolysis, the dose of drug, and the administration rate were the effects of thrombolysis. The main factor was that the drug dose was a secondary factor and there was no significant difference among various dosing schedules (P>O.05). The recanalization time and reocclusion time in the alkaline plasmin and urokinase group and the wound bleeding during operation were significant. Similar (P>0.05). Intracoronary infusion of alkaline plasmin, can cause coronary thrombosis caused by the copper ring method and urokinase thrombolytic effect.