论文部分内容阅读
杂合性白血病一词乃指有淋巴及粒细胞两者特征起源于单克隆白血病原始细胞的急性白血病。Gale及Ben-Bassat建议杂合性白血病分为“双表型”白血病及“双系”型白血病。前者指10％以上的原始细胞有淋巴及粒细胞的双重标记。后者指同时存在有淋巴细胞特征及只有粒细胞特征的不同族的原始细胞群体,但不同于有着各自克隆起源的两种截然不同白血病细胞群体的“双克隆性”白血病。“双系型”白血病应该同时或随后发生。且时间必须限于六个月内,以除外治疗诱发的白血病及“双克隆性”白血病。
The term heterozygous leukemia refers to acute leukemia characterized by both lymphoid and granulocytic origin of monoclonal leukemia blasts. Gale and Ben-Bassat suggested that heterozygous leukemia be divided into “dual phenotype” leukemia and “double line” leukemia. The former refers to more than 10% of the original cells have dual markers of lymphocytes and granulocytes. The latter refers to a heterogeneous population of primitive cells that present both lymphoid and granulocytic characteristics, but is distinct from “bi-clonal” leukemias that have two distinct leukemic cell populations with their respective origin of clones. “Two line type” leukemia should occur simultaneously or later. And the time must be limited to six months, with the exception of treatment-induced leukemia and “double clonal” leukemia.