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目的 了解呼吸窘迫综合征(respiratory distress syndrome,RDS)早产儿凝血功能相关指标的变化特点.方法 选择2015年7月-2016年10月期间入住扬州大学附属淮安市妇幼保健院的120例胎龄小于早产儿,其中符合RDS诊断早产儿60例作为观察组;对照组60例.观察早产儿PVH-IVH发生率、血浆凝血酶原时间(prothrombin time,PT)、凝血酶原时间国际标准化值(prothrombin time-international normalized ratio,INR)、部分凝血活酶时间(partial thromboplastin time,APTT)、纤维蛋白原(fibrous protein,FIB)和凝血酶时间(thrombin time,TT)的变化.结果 观察组和对照组在性别、胎龄和出生体重比较,差异均无统计学意义(均P>0.05).观察组早产儿PVH-IVH发生率(21.7%)高于对照组(8.3%),观察组PT、INR、APTT和TT的数值均高于对照组,观察组FIB均值低于对照组,差异均有统计学意义(均P<0.05).结论 RDS早产儿易发生凝血功能异常.“,”Objectives To understand the change characteristics of the levant indicators of coagulation function in preterm infants with respiratory distress syndrome(RDS). Methods From July 2015 to October 2016, 120 preterm infants(Gestational age0.05). The incidence rate of PVH-IVH in observation group(21.7%) was higher than that in control group(8.3%), the difference was statistically significant(P<0.05). The value of the plasma PT, INR, APTT, and TT of preterm infants in observation group were higher than that in control group, the difference was statistically significant(all P<0.05). The value of the plasma FIB of preterm infants in observation group was lower than that in control group, the difference was statistically significant(P<0.05). The gestational age and value of the plasma FIB of preterm infants in PVH-IVH group were lower than that in non PVH-IVH, the difference were statistically significant(all P<0.05). The value of the plasma PT, INR, APTT, and TT of preterm infants in PVH-IVH group were higher than that in non PVH-IVH, the difference was statistically significant (all P<0.05). Conclusions The abnormal coagulation function easily occurs in the preterm infants with RDS.