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采用大鼠皮下注射异丙肾上腺素（ＩＳＰ，５ｍｇ·ｋｇ－１）造成心肌缺血损伤模型。观测心肌线粒体（Ｍｉｔ）、丙二醛（ＭＤＡ）、总磷脂（ＰＬ）、胆固醇（ＣＨ）含量，超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ·Ｐｘ）活力及心肌钙含量的变化。结果发现：在注射ＩＳＰ前３０ｍｉｎ腹腔注射牛磺酸（Ｔａｕ，２００ｍｇ·ｋｇ－１），对心肌缺血损伤有保护作用，表现为能明显减少心肌Ｍｉｔ中ＭＤＡ的生成，提高ＳＯＤ和ＧＳＨ·Ｐｘ）活力，减轻磷脂的降解和心肌钙聚集作用。提示：Ｔａｕ对心肌Ｍｉｔ的保护作用可能是其抗心肌缺血损伤的重要机制之一。
Rats were injected subcutaneously with isoproterenol (ISP, 5 mg · kg-1) to induce myocardial ischemia injury model. The activities of mitochondria (Mit), malondialdehyde (MDA), total phospholipid (PL), cholesterol (CH), superoxide dismutase (SOD) and glutathione peroxidase (GSH · Px) Changes in myocardial calcium content. The results showed that intraperitoneal injection of taurine (Tau, 200 mg · kg-1) 30 min before the injection of ISP had protective effect on myocardial ischemic injury, which was shown to reduce the production of MDA and increase the activity of SOD and GSH · Px ) Vitality, reduce the degradation of phospholipids and myocardial calcium accumulation. Tip: The protective effect of Tau on myocardial Mit may be one of the important mechanisms of its anti-myocardial ischemic injury.