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关于动物休克的发病机制、病理生理过程和治疗手段已积累了大量的实验资料,但有许多问题还远未解决。在选择与人类休克病理过程相似的动物模型方面,还存在不少争论。鉴于国内对肠缺血性休克模型研究较少,我们参照Kobold方法,在狗体模拟肠缺血性休克,研究了血液动力学、血液流变学和酸硷平衡等指标的变化。材料和方法一、动物分组: 选用成年健康杂种狗16只,体重8～12kg,性别不拘,随机分为两组,实验组10只,对照组6只。二、方法: 狗禁食12小时,用3％戊巴比妥钠静脉麻醉(25mg/kg体重)。左侧股动脉插管,连接BPM—1型血压计,记录平均动脉压(MAP);左侧股静脉插管,
There are a lot of experimental data about the pathogenesis, pathophysiological process and treatment of animal shock, but many problems are still far from solved. There are still many controversies in the selection of animal models that are similar to the pathophysiology of human shock. In view of the lack of research on intestinal ischemic shock model in our country, we refer to the Kobold method to simulate intestinal ischemic shock in dogs and study the changes of hemodynamics, hemorheology and pH balance. Materials and methods First, the animal group: 16 adult hybrid dogs selected, body weight 8 ~ 12kg, sex, randomly divided into two groups, the experimental group of 10, the control group of 6. Second, the method: dogs fasted for 12 hours, with 3% sodium pentobarbital intravenous anesthesia (25mg / kg body weight). Left femoral artery catheterization, connected BPM-1-type sphygmomanometer, mean arterial pressure (MAP); left femoral vein catheterization,